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   Faculty Research-Biochemistry

Biochemistry researchers at ASU are studying and mimicking the fundamental structures and functions of biological systems, ranging from the extremely complex membrane-bound photosynthetic reaction center to the structural and functional organization of chromatin and telomeres. Ongoing projects include studies of the catalytic mechanism of metalloenzymes, the generation of color in fluorescent proteins, the investigation of biophysical processes at the single molecule level, de novo design of proteins and the construction of artificial photosynthetic systems and light driven "bio-machines". Biochemistry students collaborate with colleagues in plant and cellular biology, organic chemistry, physics and engineering. Interdisciplinary projects are designed to interface biological systems with electronic and nanotechnological devices or to study the origin and evolution of metabolic systems. Students have access to a unique range of sophisticated equipment and expertise for the study of macromolecules, including a state-of-the-art protein chemistry and mass spectrometry facility, protein X-ray crystallography, ultrafast time-resolved laser spectroscopy, as well as high-resolution electron and scanning probe microscopies.


James Allen
Professor
Protein structure and function, X-Ray crystallography, photosynthesis, bacterial cofactors

John Chaput
Assistant Professor
De novo protein evolution, in vitro selections, mRNA display, synthetic antibodies, TNA aptamers

Jiunn-Liang (Julian) Chen
Assistant Professor
Structure, function and evolution of ribonucleoprotein complexes, RNA-protein interactions, telomerase biogenesis and mechanism
Wilson Francisco
Associate Professor
Enzyme mechanisms and catalysis, enzymology, molecular biology, protein crystallography
Petra Fromme
Professor
Structural biochemistry and biophysics, membrane proteins, X-Ray crystallography, photosynthesis, molecular biology
Giovanna Ghirlanda
Assistant Professor
De-novo protein design and engineering, enzyme mechanisms, protein structure

Mark Hayes
Associate Professor
Bioanalytical chemistry, microfluidics, ultrasmall volume fluid movements and analysis

Anne Jones
Assistant Professor
Bioinorganic chemistry, electrochemistry, hydrogenases, de novo protein design and engineering, redox enzyme mechanisms, alternative energy generation.

Marcia Levitus
Assistant Professor
Biophysical chemistry, photophysics, single-molecule fluorescence, DNA-protein dynamics.

Stuart Lindsay
Professor
Scanning probe microscopy, molecular electronics, molecular biophysics, nano-scale self-assembly

Yan Liu
Assistant Professor
Nanoparticles synthesis and functionalization DNA directed self-assembly Multi-component complex structure.

Thomas A. Moore
Professor
Photosynthesis, protonmotive force, proton and electron transfer, photochemistry, photobiology, bioenergy, biocatalysis, sustainable energy, dye sensitized semiconductors

Michael Thorpe
Foundation Professor
Protein conformations and pathways, theory of disordered systems, computational methods, mathematical theory of networks

Arjan Van der Vaart
Assistant Professor
Computational chemistry, molecular dynamics, protein folding, DNA binding proteins, bacteriological toxins

Rebekka Wachter
Assistant Professor
Protein post-translational modifications, Macromolecular X-ray crystallography, Protein-based chromophores, Enzyme mechanisms

Neal Woodbury
Professor
Photosynthesis, biophysics, DNA/protein complexes, nucleosomes, optically directed molecular evolution

Hao Yan
Assistant Professor
Design and assembly of biologically inspired nanomaterials, DNA nanostructures, nanoelectronics, biomolecular imaging

Jeff Yarger
Professor
Solid-state NMR and MRI, soft matter research, disordered materials, biopolymers, battery and fuel cell materials, polyamorphism, nano-materials, high-pressure chemistry, quantum computation, laser scattering spectroscopy, neutron, electron and xray diffraction of amorphous materials