Research and Teaching Interests
Significant advances in the treatment of human cancer and other serious medical problems are becoming increasingly more dependent upon scientists well trained in organic chemistry, biochemistry and biology. Our group is organized to provide the specialized training necessary to undertake problems concerned with the discovery of anticancer substances for the treatment of cancer. Among various activities, we are pursuing a unique program concerned with isolation, structural identification and synthesis of naturally occurring anticancer agents from marine animals, plants, and arthropods. Studies concerned with synthetic methods, and routes to certain important biosynthetic products comprise related areas of interest.
Specific Research Interests: Chemistry of natural products (peptides, nucleotides, and steroids), cancer chemotherapy (anticancer agents from arthropods, marine animals and plants), and total synthesis of natural products.
"Antineoplastic Agents. 556. Isolation and Structure of Coprinastatin 1 from Coprinus cinereus," G. R. Pettit, Y. Meng, R. K. Pettit, D. L. Herald, Z. A. Cichacz, D. L. Doubek, and L. Richert, Journal of Natural Products in press (2010)
"Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10.," E. M. Prokopiou, P. A. Cooper, G. R. Pettit, M. C. Bibby, and S. D. Shnyder, Molecular Medicine Reports 3 309-313 (2010)
"Antineoplastic Agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa," G. R. Pettit, Q.-H. Ye, D. L. Herald, F. Hogan, and R. K. Pettit, Journal of Natural Products in press (2010)
"An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins," G. R. Pettit, M. D. Minardi, F. Hogan, and P. M. Price, Journal of Natural Products in press (2010)
"Isolation of Human Cancer Cell Growth Inhibitory, Antimicrobial Lateritin from a Mixed Fungal Culture," R. K. Pettit, G. R. Pettit, J.-P. Xu, C. A. Weber, and L. Richert, Planta Medica 76 500-501 (2010)