Department of Chemistry Biochemistry

JULIAN (JIUNN LIANG) CHEN

Associate Professor
Ph.D., Indiana University-Bloomington, 1997

  Office: PSE-103  Lab: PS-D114
  Phone: (480) 965-3650  Lab Phone: (480) 965-1928
  Fax: (480) 965-2747
  Email: jlchen@asu.edu

 Dr. JULIAN (JIUNN LIANG) CHEN's Lab or Group Website

Research and Teaching Interests

We are interested in understanding the structure, function and evolution of ribonucleoprotein (RNP) complexes in cells. Our attention currently focuses on the telomerase RNP enzyme, a unique reverse transcriptase essential for maintaining telomere length in most eukaryotes. Telomeres act as caps at the ends of chromosomes, and are required for chromosome stability.

Telomerase elongates telomere length by adding telomeric repeats to chromosome ends to counterbalance the natural shortening that occurs during DNA replication. Because of its role in chromosome stability, telomerase regulation is a critical step in tumorigenesis and aging. To maintain chromosome stability and infinite growth, telomerase is activated in immortal cells such as stem cells, germ line as well as 90% of human tumors. Moreover, patients with dyskeratosis congenita, a disease of premature aging, carry a mutation in the telomerase RNA (TR) or the telomerase reverse transcriptase protein (TERT) genes

Elucidation of the molecular mechanism of telomerase function is the main goal of our lab and will have significant medical implications in cancer and aging. Our goals are to understand (1) how telomerase RNP is assembled and regulated in cells, (2) how different components of the complex participate in the regulation of telomerase function, and (3) how this RNP complex evolved in different eukaryotes. Our research employes a variety of approaches involving biochemical and biophysical techniques, as well as molecular genetics and molecular biology.

Publications

"Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach. ," Y. Li, J.D. Podlevsky, M. Marz, X. Qi, S. Hoffmann, P.F. Stadler and J.J.-L. Chen, RNA 19 852-860 (2013)

"A homozygous telomerase T motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.," M.M. Gramatges, X. Qi, G.S. Sasa, J.J.-L. Chen and A.A. Bertuch, Blood 121 3586-3593 (2013)

"RNA/DNA hybrid affinity determines telomerase template-translocation efficiency," X. Qi, M. Xie, A.F. Brown, C.J. Bley, J.D. Podlevsky and J.J.-L. Chen , EMBO J. 31 150-161 (2012)

"The common ancestral core of vertebrate and fungal telomerase RNAs.," X. Qi, Y. Li, S. Honda, S. Hoffmann, M. Marz. A. Mosig, J.D. Podlevsky, P.F. Stadler, E. Selker and J.J.-L. Chen, Nucleic Acids Research 41 450-462 (2012)

"It all comes together at the ends: Structure, function, and biogenesis of telomerase," J.D. Podlevsky and J.J.-L. Chen , Mutation Research 730 3-11 (2012)