Research Interests
Our research program is highly interdisciplinary which combines Chemistry, Biology, Physics and Material Science. Our goal is to develope nanoparticle based multi-component and multi-functional nanostructures using self-assembly and DNA directed self-assembly, to characterize their unique optical properties, and explore their applications in bio-imaging, biosensing, etc.
The nanoparticles used include gold or silver nanoparticles, quantum dots, and magnetic nanoparticles. Surface modification of the nanoparticles by various bioconjugation methods will be explored to generate stable nanoparticles with desirable surface funtionalities. Self-assembly of DNA nanostructures form patterned DNA arrays, and the directed assembly of nanoparticles by the DNA templates generate uniquely functional nanodevices. Taking advantage of the precise spatial control of DNA nanostructures, and tunable size-or distance dependence of the properties of nanoparticles, multi-component structures with unique properties can be created. The various tools we use to characterize the nanoparticle based multi-compoent strucutures, include the microscopic imaging techniques of optical microscope, AFM, SEM or TEM, and spectral analysis tools, such as UV-Vis, fluorometer, surface Raman spectroscopy, etc.
Representative Publications
"Quantum Dot Bioconjugation during Core-Shell Synthesis ," Q. Wang, Y. Liu, Y. Ke, H. Yan, Angew. Chem. Int. Ed. 47, 316-319 (2008).
"Lay-by-layer Growth of Superparamagnetic and Fluorescently Barcoded Nanospheres," Q. Wang, Y. Liu, H. Yan, Nanotechnology 18, 405604 (2007).
"Spatially Addressable Multi-protein Nanoarrays Templated by Aptamer Tagged DNA Nano-architectures," R. Chhabra, J. Sharma, Y. Ke, Y. Liu, S. Rinker, S. Lindsay, H. Yan, J. Am. Chem. Soc. , in press (2007).
"Functional DNA Nanotube Arrays: Bottom-up Meets Top-down," C. Lin, Y. Liu, M. Mertig, J. Gu, H. Ya, Angew. Chem. Int. Ed. 46, 6201-6204 (2007).
"Mechanism of a Self-templating Synthesis of Monodispersed Hollow Silica Nanospheres with Tunable Size and Shell Thickness," Q. Wang, Y. Liu, H. Yan, Chem. Commun. , 2339-2341 (2007).
"A Facile One-step In situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation," Q. Wang, Y. Xu, X. Zhao, Y. Chang, Y. Liu, L. Jiang, J. Sharma, D.-K. Seo, H. Yan, J. Am. Chem. Soc. 129, 6380-6381 (2007).
"Self-assembled Peptide Nanoarrays: An Approach to Studying Protein-protein Interactions," B. Williams, K. Lund, Y. Liu, H. Yan, J. Chaput, Angew. Chem. Int. Ed. 46, 3051-3054 (2007).
"Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing," C. Lin, Y. Liu, H. Yan, Nano Lett. 7, 507-512 (2007).
"Rolling Circle Enzymatic Replication of a Complex Multi-Crossover DNA Nanostructure ," Chenxiang Lin, Xing Wang, Yan Liu, Nadrian C. Seeman,* and Hao Yan* , J. Am. Chem. Soc. 129, 14475 -14481 (2007).
"pH-driven Conformational Switch of ˇ°i-motifˇ± DNA for Reversible Assembly of Gold Nanoparticles," J. Sharma, R. Chhabra, H. Yan, Y. Liu, Chem. Commum. , 477-479 (2006).
"Rolling Circle Amplification of a DNA Nano-junction. ," C. Lin, M. Xie, J. Chen, Y. Liu, H. Yan, Angew. Chem. Int. Ed. 45, 7537-7539 (2006).
"Self-assembled Signaling Aptamer Nanoarrays for Protein Detection," C. Lin, E. Katilius, Y. Liu, H. Yan, Angew. Chem. Int. Ed. 45, 5296-5301 (2006).
"DNA tile Based Self-assembly: Building Complex Nano-architectures," C. Lin, Y. Liu, S. Rinker, H. Yan, ChemPhysChem , 1641-1647 (2006).
"Combinatorial Self-assembly of DNA Nanostructures," K. Lund, Y. Liu, H. Yan, Organic and Biomolecular Chemistry , 3402-3403 (2006).
"Two Dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex," S. Rinker, Y. Liu, H. Yan, Chem. Commum. , 2675-267 (2006).
"Addressable Molecular Tweezers for DNA templated coupling reactions," R. Chhabra, J. Sharma, Y. Liu, H. Yan, Nano Lett. 6, 978-983 (2006).
"Recognition imaging with a DNA aptamer," L. Lin, H. Wang, Y. Liu, H. Yan, and S. Lindsay, Biophysical J. 90, 4236-4238 (2006).
"DNA nanotechnology: a rapidly evolving field," K. Lund, B. Williams, Y.G. Ke, Y. Liu, H. Yan, Current Nanoscience 2, 113-122 (2006).
"A Study of DNA tube formation mechanisms using 4-, 8- and 12-helix DNA nanostructures," Y. Ke, Y. Liu, J. Zhang, H. Yan, J. Am. Chem. Soc. 118, 4414-4421 (2006).
"Periodic Square-like gold nanoparticle arrays templated by a DNA nanogrids on a surface," J. Zhang, Y, Liu, Y. Ke, H. Yan, Nano Lett. 6, 248-251 (2006).
"DNA templated self-assembly of two-dimensional and periodical gold nanoparticle arrays," J. Sharma, R. Chhabra, Y. Liu, Y. Ke, H. Yan, Angew. Chem. Int. Ed. 45, 730-735 (2006).
"Self-assembling Molecular Pegboard," K. Lund, Y. Liu, S. Lindsay, H. Yan, J. Am. Chem. Soc. 127, 17606-17607 (2005).
"Self-assembly of symmetric finite size DNA nanoarrays," Y. Liu, Y. Ke, H. Yan, J. Am. Chem. Soc. 127, 17140-17141 (2005).
"Aptamer directed Self-assembly of Proteins on a DNA Nanostructure," Y. Liu, C.X. Lin, H. Li, H. Yan, Angew. Chem. Int. Ed. 44, 4333 (2005).
"Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins.," S. H. Park, P. Yin, Y. Liu, J. Reif, T. H. LaBean, H. Yan, Nano Lett. 5, 729 (2005).
"Modular Self-assembly of DNA Lattice with Tunable Periodicity," Y. Liu, and H. Yan, Small 3, 327-330 (2005).
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