Research and Teaching InterestsOur research program is highly interdisciplinary which combines Chemistry, Biology, Physics and Material Science. Our goal is to develope nanoparticle based multi-component and multi-functional nanostructures using self-assembly and DNA directed self-assembly, to characterize their unique optical properties, and explore their applications in bio-imaging, biosensing, etc.
The nanoparticles used include gold or silver nanoparticles, quantum dots, and magnetic nanoparticles. Surface modification of the nanoparticles by various bioconjugation methods will be explored to generate stable nanoparticles with desirable surface funtionalities. Self-assembly of DNA nanostructures form patterned DNA arrays, and the directed assembly of nanoparticles by the DNA templates generate uniquely functional nanodevices. Taking advantage of the precise spatial control of DNA nanostructures, and tunable size-or distance dependence of the properties of nanoparticles, multi-component structures with unique properties can be created. The various tools we use to characterize the nanoparticle based multi-compoent strucutures, include the microscopic imaging techniques of optical microscope, AFM, SEM or TEM, and spectral analysis tools, such as UV-Vis, fluorometer, surface Raman spectroscopy, etc. |
Publications
" Control of Self-Assembly of DNA Tubules Through Integration of Gold Nanoparticles ," Sharma J, Chhabra R, Cheng A, Brownell J, Liu Y, Yan H., Science 323 112-116 (2009)
"In vivo cloning of artificial DNA nanostructures," Chenxiang Lin,Sherri Rinker,Xing Wang,Yan Liu, Nadrian C. Seeman, Hao Yan
, Proc. Nat. Acad. Sci. 105 17626-17631 (2008)
"Subtractive assembly of DNA nanoarchitectures driven by fuel strand displacement," Zhe Li, Yonggang Ke, Chenxiang Lin, Hao Yan and Yan Liu, Chem. Commun. 4318-4320 (2008)
"Self-assembled DNA nanostructures for distance dependent multivalent ligand binding," S. Rinker, Y. Ke, Y. Liu, R. Chhabra, H. Yan*, Nature Nanotechnology 418-422 (2008)
"Quantum Dot Bioconjugation during Core-Shell Synthesis ," Q. Wang, Y. Liu, Y. Ke, H. Yan, Angew. Chem. Int. Ed. 47 316-319 (2008)
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