MARK HAYES

Associate Professor
Ph.D., Pennsylvania State University, 1993

  Office: C-235  Lab: C-236
  Phone: (480)965-2566  Lab Phone: (480)727-6482
  Fax: (480) 965-2747
  Email: mhayes@asu.edu

 Dr. MARK HAYES's Lab or Group Website

Research and Teaching Interests

Long range structure of 200 nm diameter liposomes in an electric field

My research is focused on developing new technology for ultrasmall volume biological fluids and tissue analysis. New technologies will allow the full chemical and bioactive analysis of incredibly small samples—on the order of a few nanoliters or a cube about one-tenth the diameter of a human hair. The idea of these ultrasmall volume biological assays opens the door to a wide variety of revolutionary applications, including inexpensive disposable clinical assays chips, implantable micro health monitoring systems, millions of parallel assays from a single microscopic sample (proteomic and genomic application), the ability to chemically map tissues at high spatial resolution, non-invasive sampling and local disease treatment among other interesting applications. To develop and apply these new technologies, our group’s research interests span chemistry, physics, biochemistry, engineering, medical science and biology. Much of the details of accomplishing our tasks lie in fundamental issues including surface chemistry, materials design, micro- and nanofluidics, dynamic interfacial physics & chemistry, and microfluidic/microelectronic chip design and fabrication.

One long-term goal is provide truly predictive pattern recognition for early disease detection, and by definition, define various states of wellness. The earliest a disease can be detected is when the wellness state begins to falter. All of the bioanalytical technical advances can be related to developing the ability to map the detailed chemical patterns of an active biological system. This map includes the idea of pattern recognition in the sense of varying concentrations of ‘markers’ for specific disease states and pattern recognition of those concentrations over time. One of the biggest challenges in proposing to address early disease detection is defining quatitatively the baseline or normal fluctations of the operating biological system. A clearly ideal starting point for developing these capabilities is the observation of established chemical markers of stress. Arguable, a system under stress is the first step away from wellness and toward disease.

Several are closely related to the technology of microfluidics and microchip devices. For example, we are continuing to develop flow controls, pumping mechanisms, microflow monitoring systems, and materials and surface chemistries for application on microfluidic devices. Most of these involve electrokinetic effects, electroosmosis and electrophoresis. These phenomena scale to nanoscopic levels very well and can be easily controlled via simple potential fields. In addition, we have pioneered the application of supraparticle paramagnetic structures in microdevices. Another project is the illustration of electrophoretic transport of liposomes with a pH gradient across the lipid membrane. We are also developing microimmunoassays for the non-invasive sampling of bronchoalveolar lavage in murine lung for inflammatory factors. While I have an aggressive independent set of projects, I also am very active with collaborations with engineers, industry, national labs, medical researchers, among others.

Publications

"Analysis of Human Blood Serum Using the Off-Line Coupling of Capillary Isoelectric Focusing to Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry," T. Crowley and M.A. Hayes, Proteomics 5 3798-3804 (2005)

"Effects of Deformability, Uneven Surgace Charge Distributions, and Multipole Moments on Biocolloid Electrophoretic Migration," M.D. Pysher and M.A. Hayes, Langmuir 21 3572-3577 (2005)

"Lotus effect amplifies light-induced contact angle switching," R. Rosario, J.D. Gust, A.A. Garcia, M.A. Hayes, J.L. Taraci, T. Clement, J.W. Dailey and S.T. Picraux, J. Phys. Chem. B. 108 12640-12642 (2004)

"Examination of the Electrophoretic Behavior of Liposomes," M.D. Pysher and M.A. Hayes, Langmuir 20 4369-4375 (2004)

"Direct Observation of Photo-Switching in Tethered Spiropyrans Using the Interfacial Force Microscope," B.C. Bunker, B.I. Kim, J.E. Houston, R. Rosario, A.A. Garcia, M. Hayes, D. Gust and S.T. Picraux, Nano Letters 1723-1727 (2003)